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A clinical trial in Cambodia has found it possible to prolong the survival of untreated HIV-infected adults with very weak immune systems and newly diagnosed tuberculosis by starting anti-HIV therapy two weeks after beginning TB treatment, rather than waiting eight weeks, as has been standard.
During trials of preventive HIV vaccines, trial participants may develop HIV-related antibody responses that could lead to a positive HIV test by routine antibody detection methods (called vaccine-induced seropositivity/reactivity [VISP]), and the potential for false-positive test results and an incorrect HIV diagnosis, according to a new study.
Scientists have developed a new way to target viruses which could increase the effectiveness of antiviral drugs. Instead of attacking the virus itself, the method developed at the University of Edinburgh alters the conditions which viruses need to survive and multiply.
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Recent genetic association studies have uncovered a number of DNA variants associated with prostate cancer. However, some of these risk variants lie outside of genes, posing a challenge to researchers working to understand the biology of cancer. In a new study, researchers have characterized a functional DNA element associated with prostate cancer, lending new insight into the molecular mechanisms of the disease.
Light has been cast on the interaction between broccoli consumption and reduced prostate cancer risk. Researchers have found that sulforaphane, a chemical found in broccoli, interacts with cells lacking a gene called PTEN to reduce the chances of prostate cancer developing.
Chemists who specializes in cancer prevention research have reported evidence that for some dietary compounds, length of exposure over time may be key to whether or not ingestion leads to a beneficial, or detrimental, effect.
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Scientists studying two inflammation-related diseases, HIV and rheumatoid arthritis, identified changes in specific proteins linked to the action of macrophages, white blood cells that are key to the body's natural defenses. The findings could lead to early diagnosis tools and targeted therapy for diseases that stem from abnormal or uncontrolled macrophage activation, including cancer, cardiovascular disease and neurological disorders.
Men with prostate cancer lose significantly less bone mineral content (BMC) as they age than men who are free of the disease. The findings are important because loss of BMC can play a key role in the development of fragile bones, fractures and osteoporosis.
